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Xerova 10 mg is indicated as an adjunct to diet and lifestyle modification when non-pharmacological measures are insufficient, for the following conditions:
- Primary hypercholesterolaemia
- Heterozygous and homozygous familial hypercholesterolaemia
- Mixed dyslipidaemia (Fredrickson Types IIa and IIb)
- Hypertriglyceridaemia (Fredrickson Type IV)
- Dysbetalipoproteinaemia (Fredrickson Type III)
Reduction of cardiac ischaemic events in patients with asymptomatic or mild-to-moderate coronary artery disease and elevated LDL-cholesterol
Hypercholesterolaemia associated with diabetes mellitus or renal transplantation
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Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Atorvastatin is a liver-selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme involved in the conversion of HMG-CoA to mevalonate, a critical precursor in cholesterol biosynthesis. By suppressing hepatic cholesterol synthesis, atorvastatin effectively lowers elevated LDL-cholesterol levels, leading to a significant reduction in coronary events and mortality associated with coronary heart disease.
Atorvastatin decreases plasma cholesterol and lipoprotein concentrations by inhibiting HMG-CoA reductase and enhancing hepatic LDL receptor expression, thereby increasing LDL uptake and catabolism. It also reduces LDL particle production and count. In some patients, statin therapy modestly increases HDL-cholesterol, further contributing to cardiovascular risk reduction.
Although HMG-CoA reductase does not directly regulate triglyceride metabolism, atorvastatin significantly reduces triglyceride levels in patients with hypertriglyceridemia. This effect is attributed to reduced VLDL synthesis and secretion due to decreased cholesterol availability, as well as enhanced clearance of VLDL remnants via upregulated LDL receptors.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
Primary Hypercholesterolaemia and Mixed Hyperlipidaemia
Adults: Initial dose 10 mg once daily; may be titrated at intervals ≥4 weeks up to a maximum of 80 mg daily
Children (10–18 years): Starting dose 10 mg once daily; may be increased to a usual maximum of 20 mg daily
Familial Hypercholesterolaemia
Adults: Start with 10 mg daily; may be increased up to 40 mg, and if required, to a maximum of 80 mg daily (or 40 mg with an anion-exchange resin)
Children (10–18 years): Initial dose 10 mg daily; may be titrated up to 80 mg daily
Prevention of Cardiovascular Events
Adults: 10 mg once daily, adjusted according to lipid response
Geriatric Patients:
No significant differences in efficacy or safety compared with younger adults; however, elderly patients (≥65 years) may have an increased risk of myopathy and should be monitored closely.Hepatic Impairment:
Contraindicated in patients with active liver disease or persistent unexplained transaminase elevations.Pediatric Use:
Approved for use in children aged 10 years and above. Not indicated for children below 10 years of age.
✔️ Xerova 10 mg is generally well tolerated. Common adverse effects include:
Gastrointestinal disturbances (constipation, flatulence, dyspepsia, abdominal pain)
- Headache
- Back pain
- Myalgia and arthralgia
- Rash, asthenia, and mild infections
✔️ Interaction
The risk of myopathy is increased when atorvastatin is used concomitantly with cyclosporine, fibrates, erythromycin, azole antifungals, or niacin. Clinically significant interactions are uncommon with antihypertensive or antidiabetic agents. Close monitoring is advised when co-administered with digoxin, warfarin, oral contraceptives, erythromycin, colestipol, or antacids.
✔️ Contraindications:
Hypersensitivity to atorvastatin or any component of the formulation
Active liver disease or unexplained persistent elevation of hepatic transaminases
History of serious adverse reactions to HMG-CoA reductase inhibitors
✔️ Pregnancy & Lactation
Atorvastatin is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception. Therapy should be discontinued immediately if pregnancy occurs.
✔️ Precautions & Warnings
Hepatic effects: Liver function tests should be conducted before initiation and periodically during therapy
Use with caution in patients with a history of liver disease or excessive alcohol intake
Discontinue treatment if a significant elevation of CPK occurs or if myopathy is suspected
✔️ Storage:
Store in a cool, dry place, protected from light and heat. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
